Layukan tantanin halitta da aka gyara
Layukan tantanin halitta da aka gyara suna nufin sel waɗanda suka sami gyare-gyaren kwayoyin halitta ta hanyar da aka sani da gyaran kwayoyin halitta.Gyaran kwayoyin halitta ya ƙunshi yin canje-canje ga DNA na halitta, sau da yawa tare da manufar nazarin takamaiman kwayoyin halitta ko fahimtar wasu hanyoyin nazarin halittu.
Yin amfani da fasahar gyara kwayoyin halitta, yana yiwuwa a cimma layukan kunna kwayoyin halitta, layukan ƙwanƙwasa, maye gurbi, ko ƙwanƙwasa layin kwayoyin halitta a cikin takamaiman sel, waɗanda za'a iya amfani da su don nazarin aikin kwayoyin halitta, sigina, hanyoyin cututtuka. , da haɓakar ƙwayoyi, da kuma yin lakabin takamaiman ƙwayoyin cuta.
Akwai dalilai da yawa da ya sa layukan tantanin halitta da aka gyara suke da mahimmanci ga binciken kimiyya.Da farko, suna ba da kayan aiki don nazarin aikin takamaiman kwayoyin halitta.Ta hanyar canza kwayoyin halitta a cikin yanayi mai sarrafawa, masana kimiyya za su iya lura da tasirin gyare-gyaren kwayoyin halitta akan halayen tantanin halitta ko wasu hanyoyin nazarin halittu.Wannan ilimin na iya ba da gudummawa ga kyakkyawar fahimtar cututtukan ƙwayoyin cuta, da kuma gano abubuwan da za a iya magance su.
Bugu da ƙari, ana iya amfani da layin salula da aka gyara don haɓakawa da gwada sabbin magunguna.Ta hanyar gabatar da takamaiman gyare-gyaren kwayoyin halitta, masana kimiyya na iya ƙirƙirar layin salula waɗanda ke kwaikwayi yanayin cututtuka, yana ba su damar tantance tasirin yuwuwar jiyya.Wannan yana ba da damar ƙarin ingantattun hanyoyin haɓaka magunguna masu inganci.
Haka kuma, layukan tantanin halitta da aka gyara suna da yuwuwar aikace-aikace a cikin magani mai sabuntawa.Ta hanyar gyaggyara kwayoyin halittar da ke da alhakin halayen tantanin halitta ko bambance-bambance, masana kimiyya na iya haɓaka yuwuwar warkewar ƙwayoyin sel ko ƙirƙirar sel waɗanda suka fi dacewa da dasawa.
Amfani
1. Wuraren da aka gyara Gene-edited Multi-locus a lokaci guda;
2. samar da sabis na tsayawa ɗaya daga ƙirar sgRNA da haɗin kai zuwa nunin layin salula;
3. Ƙwarewa mai wadata a cikin haɗaɗɗun kwayoyin halitta don taimakawa masu gyara kwayoyin halitta daga ƙirar ƙira zuwa kammala ginin.
Babban Kasuwanci
- Layin Kwayoyin Halittar Halitta
- Layin Kunna Halitta Halitta
- Nuna mutant cell Lines
- Knock-in Cell Lines
Magana
[1]Zhang S, Shen J, Li D.Theranostics.2021 Jan1; 11 (2): 614-648.doi: 10.7150/thno.47007.PMID: 33391496;Saukewa: PMC7738854.