Tsawon gyaran kwayoyin halitta ta hanyar fasahar gargajiya yawanci bai wuce 5kb ba, kuma tsawon guntun da aka gyara yana rage yawan nasarar.Bugu da ƙari, don gina samfurin linzamin kwamfuta na dogon lokaci ta hanyar amfani da fasaha na al'ada, ƙwayoyin chimeric suna buƙatar ƙirƙira kuma a duba su don tsararru 2-3 don samun berayen da aka yi niyya, kuma gabaɗayan tsarin yana ɗaukar fiye da 10- watanni 12.
Fa'idodin gyaran gyare-gyare na dogon gutsuttsura kwayoyin halitta sun ta'allaka ne a cikin ikonsa na shawo kan wasu iyakoki na hanyoyin gyaran kwayoyin halitta na gargajiya.
